ECO-FRIENDLY SYNTHESIS AND ANTIFUNGAL PROPERTIES OF N-SALICYLHYDRAZONES DERIVATIVES
DOI:
https://doi.org/10.31413/nat.v14i2.20347Palabras clave:
salicylhydrazones, Fusarium sp., Corynespora cassiicola, green synthesisResumen
The growing demand for cleaner and more sustainable chemicals has positioned Green Synthesis as an important cornerstone of modern Organic Synthesis. In this context, N-salicylhydrazone derivatives, compounds with a broad range of pharmacological potential, were synthesized using four distinct green methodologies: magnetic stirring at room temperature, microwave-assisted reactions, ultrasound irradiation, and mechanochemistry. The synthetic routes avoided the use of toxic solvents, minimized purification steps and afforded high to excellent yields (56.64-94.07%). The chemical structures were elucidated by FT-IR and NMR spectroscopy. The antifungal activity of the derivatives was evaluated against Fusarium sp. and Corynespora cassiicola, two phytopathogens of significant agricultural relevance. Nine compounds exhibited inhibitory effects, with the 3-nitro-substituted derivative (compound 2) showing the highest % growth inhibition (33.67% for Fusarium sp. and 30.77% for C. cassiicola). The results demonstrate the potential of N-salicylhydrazones as promising chemical structures for the development of alternative antifungal agents. Overall, this study highlights the relevance of clean synthetic methodologies for the advancement of sustainable chemistry and the discovery of bioactive molecules with promising applications in crop protection.
Keywords: salicylhydrazones; Fusarium sp.; Corynespora cassiicola; green synthesis.
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